Back
Home » Health
  •  
    Filmi Bollywood
    • Kiara Advani Unveils Trailer For Netflix Thriller Film Guilty: Nails Grunge Chic Look
    • Wendell Rodricks’ Husband Jerome Marrel Posts A Heartfelt Note For Late Designer
    • Karan Johar Quashes The Rumours Of Making Student Of The Year 3 With Suhana Khan & Asim Riaz
    • Karan Johar Shuts Down Rumours Of Launching Suhana Khan with Asim Riaz in Student Of The Year 3
    • It’s Official! Taapsee Pannu, Tahir Raj Bhasin To Feature In Hindi Remake Of Run Lola Run
    • Ishaan Khatter Shocked Everyone On Khaali Peeli Set By Doing His Own Stunts, Without Harness
    • Vicky Kaushal On His Ideal Date: ‘My Kind Of Date Is Where It Is Just Me, Her And Nature’
    • Taapsee Pannu Says Success Has Given Her Confidence That Her Choice Of Films Are Right
    • Dabboo Ratnani Shares BTS Videos Of His Calendar Shoot Featuring Vidya Balan, Vicky Kaushal & More
    • Kareena Kapoor Khan Talks About Her Character In Laal Singh Chaddha: People Will Be Shocked
    • Tara Sutaria Reveals She Is Doing Something People Would Not Expect In Her Next Film Tadap
    • Sara Ali Khan Once Wanted To Fake A Cardiac Arrest To Escape Film Narration!
    • Disha Patani Is A Lucky Charm For All Her Co-Stars; Has Given Them Their Biggest Box-Office Hits!
    • Ayushmann Khurrana Is Proud Of India For The Progressiveness It Has Shown
    • Mr. India Trilogy In The Making; Ali Abbas Zafar To Write And Direct
    • Sara Ali Khan Reveals Why She Gets Suspicious Looks From The US Airport Officials
Genetically Engineered Human Miniature Livers To Help Test Medicines & Study Diseases
Boldsky | 13th Aug, 2019 08:00 PM

Reports suggest that the research team at the University of Pittsburgh School of Medicine has developed the first-ever genetically modified mini human livers. The GM mini livers have been grown in the laboratory at the university to mirror the functions and actions of liver disease progression and test therapeutics.

First, of it's kind, the team of researchers transformed the genetically engineered human cells into functional, three-dimensional (3D) liver tissue that mimics non-alcoholic fatty liver disease (NAFLD), a condition which causes fat buildup in the liver and leads to cirrhosis or even liver failure .

Alejandro Soto-Gutierrez, an associate professor at the University of Pittsburgh pointed out, "This is the first time we can create genetically engineered human mini livers with a disease using stem cells in the lab".

Also read: World Hepatitis Day 2019: Does Drinking Alcohol Cause Hepatitis?

The monumental scientific invention is not just limited to understanding the causes of diseases but also helps in assessing the progression of diseases. Apart from that, the GM mini livers will also help in testing therapeutics as well, supports a study published in the journal Cell Metabolism.

However, the researchers say that it is not uncommon for drugs to fail in the clinical trials even if they have had achieved success in being tested in mice. That is, although the drug may be effective in mouse models it will not be effective in the human trials .

Soto-Gutierrez said, "Mice aren't humans. We are born with certain mutations, polymorphisms, that will predispose us to certain diseases, but you can't study polymorphisms in mice, so making a mini customised human liver is advantageous." Hence, resulting in the development of the genetically modified mini livers.

The researchers began by genetically engineering the normal human skin cells, to develop a chemically activated switch that possesses the ability to tamp down the SIRT1 gene. Then, the cells were reprogrammed back to their stem cell state and turned into liver cells. The researchers implanted the GM human liver cells into rat livers stripped of their cells, which was then converted into functional 3D mini livers, with blood vessels and structural features of a normal organ .

Once the GM mini livers were mature, the researchers suppressed the SIRT1 gene by flipping the genetic switch, which resulted in the bioengineered mini livers to resemble the metabolic dysfunction found in tissues obtained from individuals with fatty liver disease .

Also read: Study Reveals A New Drug May Help Treat Brain Tumours

The researchers pointed out that, "the GM lab-grown mini livers provide a ready and reliable test-bed for drugs at all stages of disease progression" and added that these mini livers are not yet ready to be applied in clinical applications any time soon but resolutely states that this will be a great addition to the scientific field in the near future .

   
 
Health and Life
  • 10 Fruits To Avoid For Diabetes
  • List Of Diseases Caused By Smoking
  • 17 Foods To Eat And Avoid Before Travelling
    • Vitamin K Deficiency: Causes, Symptoms, Diagnosis, Treatment And Prevention
    • 11 Reasons Why You Should Be Drinking Potato Juice
    • 7 Different Ways To Eat Honey For Weight Loss
      • Ways To Use Mint (Pudina) Leaves For Weight Loss
      • 10 Foods To Combat Stomach Gas
      • 8 Morning Habits That Can Cause Weight Gain
        • 7 Risks Associated With Iron Overload
        • 9 Science-backed Benefits Of Intermittent Fasting
        • Top 21 Foods To Build Muscle
          • 10 Healthy Foods To Combat Period Acne
          • 10 Foods To Flush The Nicotine Out Of The Body
          • 7 Benefits Of Eating Poha For Breakfast
            • 10 High Fibre Vegetables To Lose Weight Easily
            • 10 Best Foods With Good Fat For Weight Loss
            • 7 Ways To Include Apple In Your Diet
              • 8 Sour Foods For Weight Loss
              • From Losing Weight To Improving Digestion, Here Are The Impressive Health Benefits Of Hot Water
              • Can You Eat Pani Puri When Trying To Lose Weight?