Home » Health
    Filmi Bollywood
    • Vikrant Massey Reveals His Birthday Plans & It’s Every Bit Cute!
    • After Sister Rhea Kapoor, Sonam Kapoor To Produce A Film With Husband Anand Ahuja
    • Sana Saeed, Stuck In US, Shares Her Ordeal After She Lost Her Father On Janta Curfew Day!
    • Jacqueline Fernandez Amid COVID-19 Lockdown: 'I Wanted My Parents To Be With Me Right Now'
    • ‘Kanika Kapoor Was Asked To Change Clothes Behind A Curtain’ Says Her Family
    • Ranbir Kapoor-Alia Bhatt's Wedding Functions To Begin From This Date? An Insider Spills The Beans!
    • Taapsee Pannu Shares Picture Of Her Tattoo Trial For Pink: Girls Wanted Similar Tattoos Afterwards
    • After Badshah, Singer Payal Dev Reacts To 'Genda Phool' Credit Row!
    • Shah Rukh Khan And Red Chillies Announce 7 Initiatives For Fighting COVID-19!
    • Kareena Kapoor Khan Trolls Arjun Kapoor When He Tells His Male Fans To Take Charge Of House Chores
    • Rishi Kapoor Requests People To Not Indulge In Violence During ‘Coronavirus War’
    • Vicky Kaushal Says He Will Meet His Loved Ones Soon After Lockdown; Does That Include Katrina Kaif?
    • Karisma Kapoor Pledges To Donate To PM-CARES And Maharashtra CM’s Relief Fund
    • COVID-19: Milind Soman Goes Out On Mumbai Streets For Groceries Amid Lockdown; Shares Photos
Stool Transplant Effective For Treating Intestinal Disorders, Claims Study
Boldsky | 5th Dec, 2019 03:30 PM

A recent study conducted by researchers at the University of Adelaide suggests an effective treatment for ulcerative colitis, a type of inflammatory bowel disease (IBD). The study asserted that faecal microbiota transplantation (FMT), commonly termed as 'poop transplant' can be effective in the treatment of intestinal disorders, especially ulcerative colitis.

What Is Poop Transplant?

Although the term may sound silly, it is the commonly used term for faecal microbiota transplant (FMT) which also goes by the name stool transplant. FMT is the process of transplantation of faecal bacteria from a healthy individual into a recipient, by restoring the colonic microflora by introducing healthy bacterial flora through the infusion of stool.

The process is done through colonoscopy, enema, orogastric tube, or by mouth in the form of a capsule containing freeze-dried material, obtained from a healthy donor. FMT has been widely used for the treatment of Clostridioides difficile infection (CDI), which can cause diarrhoea to pseudomembranous colitis .

FMT has been used experimentally to treat other gastrointestinal diseases, including colitis, constipation, irritable bowel syndrome, and neurological conditions such as multiple sclerosis and Parkinson's .

And the recent study by the group of researchers asserted that the treatment method has aided in improving the condition of people affected by intestinal disorders. Let's take a detailed look at the study.

FMT Can Improve The Symptoms And Reduce The Severity & Pain

Upon carrying out the study, the researchers found out that FMT can help in improving the symptoms, as well as, reducing the severity of intestinal disorders. It was ascertained that the treatment is increasingly beneficial for ulcerative colitis, a type of inflammatory bowel disease (IBD) that leads to inflammation of the large intestine and the rectum .

The treatment was effective in individuals who had mild to moderate ulcerative colitis. Ulcerative colitis is one of the diseases that fall under the broad umbrella of Inflammatory bowel disease IBD . Ulcerative colitis can range in severity. Symptoms can include bloody diarrhoea, abdominal pain and cramps, rectal pain or bleeding, weight loss, fatigue, and fever.

FMT involves the transfer of helpful gut bacteria from the healthy donor so the person with IBD, with the hope of regaining the balance to their gut microbiome. The study made use of 73 adults who had mild to moderately active ulcerative colitis. The respondents were divided into two different groups, where one was given FMT that was prepared in an oxygen-free environment and the others were given their own stool through a colonoscopy, followed by two enemas over the course of seven days.

Consequently, the results suggested that preparing the FMT in an oxygen-free zone led to a 32 per cent remission rate for the disease; whereas only 9 per cent was reported in individuals who were given the placebo.

Anaerobic Preparation Played A Major Role In Treatment Effectiveness

The researchers were able to assimilate that preparing the samples without oxygen seemed to be key for this treatment . The lead author of the study said, "many gut bacteria die with exposure to oxygen and we know that with anaerobic stool processing, a large number of donor bacteria survive so that they can be administered to the patient."

They assumed the aforementioned to be the reason that the treatment helped in providing a therapeutic effect in the respondents with ulcerative colitis. Unlike the traditional treatment methods that aim at the person's immune system to reduce inflammation, FMT centralises on the person's gut microbiome, which regulates a person's gastrointestinal tract .

FMT Helped Restore The Microbial Balance

The treatment method was effective in managing the symptoms and easing the pain and severity because the treatment helped in restoring the normal microbial balance and thereby promoting the reduction of inflammation caused by ulcerative colitis [3]. Although it is understood that the treatment has a positive impact on individuals with intestinal disorders, there is ambiguity in the exact reason how.

The study has gained prominence due to its differential approach adopted, which focused on the preparation style of the FMT, which was supported by the head researcher who went on to state that, "many bacteria living in the gastrointestinal tract thrive in an oxygen-free (anaerobic) environment and struggle to survive when exposed to an oxygen-containing (aerobic) situation. Previous FMT studies exposed the stool to oxygen during processing, potentially killing many of the anaerobic bacterial species." .

On A Final Note...

The researchers are currently in the process of studying the means to develop rationally designed microbial therapies that can replace FMT, which will have the healthy gut bacteria in a pill; thereby avoiding the need to take whole faeces. In addition to that, the researchers are also looking at ways to ascertain whether FMT can maintain remission in ulcerative colitis .

Health and Life
  • Nutrition Tips For People With Epilepsy
  • How To Mind Our Minds During COVID-19 Lockdown
  • Coronavirus And Cancer Patients: What You Need To Know
    • World Autism Awareness Day: What Is High-Functioning Autism? Its Causes And Diagnosis
    • COVID-19: How Does Quarantine Affect Your Mental Health?
    • 10 Best Kitchen-Friendly Herbs To Boost Immunity During COVID-19
      • Coronavirus Linked To Heart Disease, Says Study
      • 5 Best Fruits To Eat During Pregnancy
      • COVID-19: What Is Community Transmission? Has It Affected India Yet?
        • Coronaviurus: What Is Covid-19 Pneumonia? How Does It Affect The Lungs?
        • Obese People Are At An Increased Risk Of Contracting COVID-19, Says Study
        • Coronavirus: US Doctors Identify A Drug Combination Suitable For Covid-19 Treatment
          • Covid-19 Lockdown: Simple Exercises You Can Do At Home
          • What Is Convalescent Plasma Therapy? Is It Effective To Fight COVID-19?
          • Coronavirus Face Masks: Types, When And How To Use
            • Are Pets At The Risk Of Coronavirus?
            • What Is Bioterrorism?
            • How To Take Care Of A Patient With Suspected Or Confirmed COVID-19
              • Tips For A Healthy Work From Home During Covid-19 Lockdown
              • Can Vitamin C Help Prevent COVID-19?
              • 15 Deadly Viruses In Human History Apart From COVID-19